Stem cells are "mother cells" (undifferentiated or immature) that have not yet undergone the processes of transformation into specialized cells of which are made different human tissues and organs. Stem cells remain undifferentiated or immature until a stimulus intervenes to encourage them to develop into specialized cells to fulfill a specific function (to become cells of organs or tissues).

Stem cells can be embryonic or adult:

embryonic stem cells, which are found in the embryo from conception until the 4th day of gestation, are totipotent, that is, capable of giving life to all the specialized cell types adult stem cells present in umbilical cord blood, bone marrow, peripheral blood and adipose tissue, are multipotent, that are able to transform in some specialized cell types.

Stem cells from the umbilical cord

Are adult stem cells that have the ability to transform into all cells of the blood. They are gathered on the occasion of the birth, whether natural or c-section, drawing the blood from the umbilical cord just cut off. The collection procedure is safe and painless, for both the mother and the baby, since it occurs after birth, in the period preceding the disposal of the cord.

Childbirth is the only occasion in the course of an individual's life, in which it is possible to collect the own stem cells in a non-invasive and to preserve them for the use dedicated to the baby or to a family member. The blood contained in the umbilical cord blood, rich in stem cells, can be harvested with a simple and risk-free procedure, before the cord will finish in the "special waste" of the hospital. Stored stem cells from umbilical cord blood can be used in the event of outbreaks of serious diseases, on the unborn child or on any compatible relative, after evaluation of clinical pertinence. More than 20,000 transplants of cord blood stem cells (Source: Gluckman et al., Cord blood transplantation: state of the art. Haematol.2009) performed worldwide for the treatment of many diseases, confirm the importance and the scientific validity of the conservation. The most part of investments in research, that were once engaged in the pharmaceutical industry, are now diverted in the field of stem cells, making possible the further development of clinical applications.

Dedicated

Conservation is defined as autologous when the stem cells contained in umbilical cord blood are preserved for the benefit of the newborn (autologous use) or its compatible relatives (use heterologous among blood relatives). This type of conservation is defined dedicated and can be obtained at no cost to the National Health Service when at birth or prenatal stage, the baby or a blood relative are infected by a disease, or in the case of relatives at risk of having children affected by genetically determined diseases. Source (OJ General Series n. 303, 31 December 2009 - DECREE 18 November 2009). The data reported by the National Blood Centre indicate 2176 of performed dedicated preservations (of which 242 in 2010). For preventive purposes, however, you can make the storage dedicated to the baby or to relatives at private facilities, such as Bioscience Institute.

Heterologous

The donation consists of making available to the public stem cells extracted from umbilical cord blood. In this case, after verification of suitability of parents, the umbilical cord blood is collected at the time of birth and the extracted cells are preserved at a public bank Italian for free. In case of necessity, they are given to anyone who might need it for a transplant, after verification of compatibility. In 2009 and 2010 donations of cord blood were approximately 17,000 (per year), of which about 4,000 (per year) actually stored in public banks. The numerical disparity between donations and stem cell samples actually stored depends on the specific requirements that those samples, intended for transplantation on subjects unrelated to the donor, must necessarily have. Most of these requirements do not apply in the case of autologous, because the cells are intended to be preserved on the donor (the baby) or on a compatible relative (f.e. Sibling).

Hematopoietic stem cells are used in the treatment of severe hematological, immunological, metabolic, genetic and oncological diseases. To date, in fact, more than 20,000 heterologous and autologous stem cell cord blood transplants have been performed (Source: Gluckman et al., Cord blood transplantation: state of the art. Haematol.2009). Recent developments in the field of scientific research have allowed the recovery of patients affected by serious genetic diseases for which there was no cure.


Leukemia and lymphoma
• Acute lymphoblastic leukemia
• Acute myeloid leukemia
• Acute biphenotypic leukemia
• Acute undifferentiated leukemia
• Leukemia / T-cell lymphoma of adult
• Hodgkin's Lymphoma
• Non-Hodgkin's Lymphoma
• Chronic lymphocytic leukemia
• Prolymphocytic leukemia

Hemoglobinopathies
• Beta Thalassemia
• Sickle cell anemia
• Transfusion-dependent pyruvate kinase deficiency

Histiocytosis
• Hemophagocytic lymphohistiocytosis family
• Griscelli
• Chediak-higashi syndrome<
• Langerhans cell histiocytosis (histiocytosis x)

Other neoplasms
• Ewing's Sarcoma
• Neuroblastoma
• Clear cell carcinoma of the kidney
• Rhabdomyosarcoma

Other indications
• Evans Syndrome
• Lymphoproliferative syndrome autoimmune
• Progressive systemic sclerosis
• Neoplasms in children treated with chemo / radiotherapy

Myeloproliferative disorders myelodysplastic
Myelodysplastic syndromes, including:
• Refractory anemia (RA)
• Refractory anemia with ringed sideroblasts (RARS)
• Refractory anemia with excess blasts (RAEB)
• Refractory anemia with excess blasts in transformation (RAEB-t)
• Chronic myelomonocytic leukemia
• Juvenile myelomonocytic leukemia
• Refractory cytopenia
Philadelphia-chromosome positive chronic myeloid leukemia
Idiopathic myelofibrosis
Polycythemia vera
Essential thrombocythemia

Osteogenesis imperfecta

Congenital disorders of the immune system
Chronic granulomatous disease
Deficiency of leukocyte adhesion proteins
Severe combined immunodeficiency (SCID), including:
• Deficiency of adenosine deaminase
• Defect of HLA class I and II
• Lack of Zap70
• Omenn syndrome
• Deficit of purine-nucleoside phosphorylase
• reticular dysgenesis
• Defect of the common gamma chain cytokines in multiple
• Lack of JAK3
Hyper-IgM syndrome
Wiskott-Aldrich
Duncan syndrome or syndrome Purtillo
Hypoplasia cartilage-scalp
DiGeorge Syndrome
IPEX syndrome

Other inherited disorders
• Gunther Disease

Plasma cell disorders
• Multiple Myeloma
• Plasma cell leukemia
• Waldenstrom's Macroglobulinemia
• Amyloidosis

Bone marrow deficiencies mono / plurilineari
• Acquired Aplastic anemia
• Fanconi anemia
• Dyskeratosis congenita
• Paroxysmal nocturnal hemoglobinuria
• Diamond-Blackfan Anemia
• Anemia, congenital dyserythropoietic
• Acquired pure erythroid aplasia
• Purple Congenital amegakaryocytic
• Disease-Bernard Soullier, thrombasthenia Glanzmann's
• Congenital agranulocytosis (syndrome Kostmann)
• Shwachman-Diamond Syndrome

Inborn errors of metabolism
• Hurler syndrome (MPS-IH)
• Scheie syndrome (MPS IS)
• Maroteaux-Lamy Syndrome (MPS VI)
• Sly syndrome (MPS VII)
• Adrenoleukodystrophy
• Fucosidosis
• Gaucher Disease
• Krabbe disease
• Mannosidosis
• Metachromatic leukodystrophy
• Mucolipidosis II (I-cell disease)
• Batten disease
• Sandhoff disease
• Osteopetrosis

Source: G.U. General Series n. 303 of 31 December 2009
DECREE 18 November 2009 (Annex 1)

In Italy, the conservation for autologous use (in favor of the newborn) or allogeneic intra-family (in favor of relatives) can be obtained from the National Health Service only if the child or family member found to be infected by a disease, or in the event that the family are at risk of having children with genetically determined diseases, this type of storage is called "dedicated" (Dec.18/11/2009 - OJ of 31/12/2009) and is free of charge. The data reported by the National Blood Centre indicate 2176 of performed dedicated preservations (of which 242 in 2010).

In all other cases, the family can make a donation of cord blood or require the health department of the hospital where the birth will take place the authorization to import stem cells from cord blood to keep them to a private company (State-Regions Agreement April 29, 2010).

Following the Agreement, the task to authorize exports of umbilical cord blood for autologous use has been entrusted to the health departments of the childbirth structures.

The task of verifying, as established in the Agreement referred above, certain requirements of citizens applicants, as well as the characteristics of the receiving exportation Bank, is in fact delegated to the Health Management. The Law 219 of 21 October 2005 also states that stem cells may not be the subject of profit and punishes any activity which, directly or indirectly, produces a profit from them if they were comparable to the blood and organs.

In the first 180 days of storage (quarantine period) stem cells are stored in a temporary container. After the quarantine period, the mother repeats the same tests carried out in the last 30 days of gestation:

► Anti HIV 1 e 2
► Anti HCV
► HBsAg
► Anti-HBc
► TPHA
► Anti HTLV 1 e 2

Once the negative results of the examinations have been confirmed, the cells are placed in a permanent storage container. The quarantine is a mandatory requirement by law, failure to observe the period of quarantine makes the preserved cells unusable because they are lacking the requirement of "biosafety".

Source: D.Lgs. n°16 del 2010.

Scientific Studies In order to facilitate a more comprehensive access to information related to current and future therapeutic perspectives of cord blood stem cells, this section collects works of scientific activity in this field of research The collection and regular updating of publications is prepared by the Scientific Committee of Bioscience Institute.

Date Jurnal Headline Authors Link
2015 Jul Genet Mol Res. Transplantation of umbilical cord blood mononuclear cells increases levels
of nerve growth factor in the cerebrospinal fluid of patients with autism.
Li Q1, Chen CF2, Wang DY3, Lü YT3, Huan Y3, Liu M3, Ge RC3, Chen XW3, Qi HS3, An L3, Hu X4.
2015 Jun Umbilical cord blood graft engineering: challenges and opportunities. Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells
in patients with type 2 diabetes.
P A Thompson, K Rezvani, C M Hosing, B Oran, A L Olson, U R Popat, A M Alousi, N D Shah, S Parmar, C Bollard, P Hanley, P Kebriaei, L Cooper, J Kellner, I K McNiece and E J Shpall.
2015 May Exp Ther Med. Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells
in patients with type 2 diabetes.
Guan LX1, Guan H2, Li HB1, Ren CA3, Liu L4, Chu JJ1, Dai LJ5
2015 Mar J Thorac Cardiovasc Surg Regenerative therapy for hypoplastic left heart syndrome:
first report of intraoperative intramyocardial injection of
autologous umbilical-cord blood-derived cells.
Burkhart HM1, Qureshi MY2, Peral SC3, O'Leary PW2, Olson TM2, Cetta F2, Nelson TJ4; Wanek Program Clinical Pipeline Group
2014 Clin Lab. Umbilical cord mesenchymal stem cell transfusion ameliorated
hyperglycemia in patients with type 2 diabetes mellitus.
Kong D, Zhuang X, Wang D, Qu H, Jiang Y, Li X, Wu W, Xiao J, Liu X, Liu J, Li A, Wang J, Dou A, Wang Y, Sun J, Lv H, Zhang G, Zhang X, Chen S, Ni Y, Zheng C.
2014 Nov Cell Transplant. The potential of human umbilical cord-derived mesenchymal
stem cells as a novel cellular therapy for multiple sclerosis.
Li JF1, Zhang DJ, Geng T, Chen L, Huang H, Yin HL, Zhang YZ, Lou JY, Cao B, Wang YL.
2014 Feb Obstet Gynecol Int. Autologous cord blood therapy for infantile cerebral palsy:
from bench to bedside.
Jensen A
2012 Apr Br Med Bull Umbilical cord blood stem cells: clinical trials in
non-hematological disorders
Ilic D, Miere C, Lazic E
2012 Mar Dermatol Surg. A Multicenter, Double-Blind, Placebo-Controlled Trial of Autologous Fibroblast
Therapy (Azficel-T) for the Treatment of Nasolabial Fold Wrinkles.
Smith SR, Munavalli G, Weiss R, Maslowski JM, Hennegan KP, Novak JM.
2012 Mar Blood Cells Mol Dis. Human umbilical cord is a unique and safe source of various types of
stem cells suitable for treatment of hematological diseases and
for regenerative medicine
Elvira Pelosi, Germana Castelli, Ugo Testa
2012 Jan Stem Cells Concise review: cord blood banking, transplantation and induced pluripotent
stem cell: success and opportunities
Rao M, Ahrlund-Richter L, Kaufman DS.
2011 Mar Blood Hematopoietic stem/progenitor cells, generation of induced pluripotent stem
cells, and isolation of endothelial progenitors from 21-23.5 year cryopreserved
cord blood
Broxmeyer HE, Lee MR, Hangoc G, Cooper S, Prasain N, Kim YJ, Mallett C, Ye Z, Witting S, Cornetta K, Cheng L, Yoder MC.
2011 Jan J Pediatr Hematol Oncol. Cord blood transplantation in children with relapsed or refractory
severe aplastic anemia.
Jaing TH, Huang IA, Chen SH, Yang CP, Liang DC, Hung IJ.
2010 Sep Int J Mol Sci Human Umbilical Cord Blood Stem Cells:
Rational for Use as a Neuroprotectant in Ischemic Brain Disease
Hadar Arien-Zakay, Shimon Lecht, Arnon Naglerand Philip Lazarovici
2010 Jul Nature Protocol Optimized multiparametric immunophenotyping of umbilical cord blood cells by flow cord blood and murine bone marrow transplantation K Mizrahi, J Stein, M Pearl-Yafe, O Kaplan,I Yaniv and N Askenasy
2010 Jun Exp Clin Transplant Treatment of diabetic impotence with umbilical cord blood
stem cell intracavernosaltransplant: preliminary report of 7 cases
Bahk JY, Jung JH, Han H, Min SK, Lee YS.
2010 Jun Reuter Cord blood transplants a viable option in leukemia Julie Steenhuysen
2010 Jun Tissue Engineering Part A Umbilical Cord Stem Cell Seeding on Fast-Resorbable
Calcium Phosphate Bone Cemen
Hockin H.K. Xu, Liang Zhao, Michael S. Detamore, Shozo Takagi, Laurence C. Chow.
2010 May Annals of Hematology Double umbilical cord blood transplantation
for children and adolescents
Hyoung Jin Kang1, Keon Hee Yoo2, Ji Won Lee1, Hyery Kim1, Soo Hyun Lee2, Ki Woong Sung2, Kyung Duk Park1, Hong Hoe Koo2, Hee Young Shin1 and Hyo Seop Ahn
2010 May CBR Lyophilized Heparin Preserves Cord Blood Stem Cells
Better Than Commonly-Used Anticoagulant, Citrate Phosphate Dextrose
 
2010 May Broxmeyer HE. Cord blood hematopoietic stem cell transplantation. StemBook
2010 Jun experimental hematology Induction of pluripotency in human cord blood−unrestricted
somatic stem cells
Holm Zaehresa, Gesine Köglerb, Marcos J. Arauzo-Bravoa, Martina Bleidissela, Simeon Santourlidisb, Sandra Weinholdb, Boris Grebera, Jeong Beom Kima, Anja Buchheiserb, Stefanie Liedtkeb, Hanna M. Eilkena, Nina Graffmannb, Xiaoyi Zhaob, Johann Meyerc, Peter Reinhardta, Boris Burra, Simon Waclawczykb, Claudia Ortmeiera, Markus Uhrbergb, Hans R. Schölerac, Tobias Cantzac, Peter Wernet
2009 Folia Biol (Praha) In vivo differentiation of human umbilical cord blood-derived cells into
insulin-producing beta cells.
Koblas T, Zacharovová K, Berková Z, Leontovic I, Dovolilová E, Zámecník L, Saudek F.
2009 Dec Dtsch Arztebl Int Stem cells derived from cord blood in
transplantation and regenerative medicine
Reimann V, Creutzig U, Kögler G.
2008 Jun Reprod Biomed Online Placental mesenchymal and cord blood stem cell therapy for
dilated cardiomyopathy
Ichim TE, Solano F, Brenes R, Glenn E, Chang J, Chan K, Riordan NH.
2008 Jun Curr Opin Hematol New insights into cord blood stem cell transplantation Tse W, Bunting KD, Laughlin MJ.
2008 Minim Invasive Ther Allied Technol Stem cell-based therapy in gastroenterology and hepatology Piscaglia AC, Novi M, Campanale M, Gasbarrini A.
2008 May Nippon Rinsho Cell source for regenerative medicine Umezawa A, Makino H.
2007 Methods Mol Biol Immune properties of mesenchymal stem cells Sotiropoulou PA, Papamichail M.
2008 May J Gastroenterol Hepatol Liver stem cells: a scientific and clinical perspective Dan YY, Yeoh GC.
2008 Jun Clin Immunol Umbilical cord blood transplantation: basic biology and clinical challenges
to immune reconstitution
Brown JA, Boussiotis VA.
2008 Jun Exp Hematol Autologous umbilical cord blood infusion for type 1 diabetes Haller MJ, Viener HL, Wasserfall C, Brusko T, Atkinson MA, Schatz DA.
2008 Feb JAMA Clinical applications of blood-derived and marrow-derived stem cells
for nonmalignant diseases
Burt RK, Loh Y, Pearce W, Beohar N, Barr WG, Craig R, Wen Y, Rapp JA, Kessler J.
2008 Int J Dev Biol A novel, neural potential of non-hematopoietic human umbilical
cord blood stem cells
Domanska-Janik K, Buzanska L, Lukomska B.
2008 May Br J Haematol Cord blood stem cell transplantation for haemoglobinopathies Pinto FO, Roberts I.
2007 Acta Neurobiol Exp (Wars) Human cord blood cells can differentiate into retinal nerve cells Koike-Kiriyama N, Adachi Y, Minamino K, Iwasaki M, Nakano K, Koike Y, Yamada H, Mukaide H, Shigematsu A, et all
2008 Jun J Neurosci Res Neural differentiation and potential use of stem cells from the
human umbilical cord for central nervous system
transplantation therapy
Low CB, Liou YC, Tang BL.
2008 Jan Semin Hematol Allogeneic stem cell transplantation for myelodysplastic syndrome Barrett AJ, Savani BN.
2008 Jan Biol Blood Marrow Transplant State of the art review: HLA matching and outcome of unrelated
donor umbilical cord blood transplants
Kamani N, Spellman S, Hurley CK, Barker JN, Smith FO, et all
2008 Jan Regen Med Blood into beta-cells: can adult stem cells be used as a therapy
for Type 1 diabetes?
Palma CA, Lindeman R, Tuch BE.
2008 Mar Bone Marrow Transplant Unrelated donor allogeneic transplantation for adult acute
lymphoblastic leukemia: a review
Bachanova V, Weisdorf D.
2008 Mar JAMA Clinical applications of blood-derived and marrow-derived
stem cells for nonmalignant diseases
Burt RK, Loh Y, Pearce W, Beohar N, Barr WG, Craig R, Wen Y, Rapp JA, Kessler J.
2008 Mar Biol Blood Marrow Transplant Collection and preservation of cord blood for personal use Ballen KK, Barker JN, Stewart SK, Greene MF, Lane TA
2008 Mar Bone Marrow Transplant Umbilical cord blood transplantation in adult myeloid leukemia Tse WW, Zang SL, Bunting KD, Laughlin MJ.
2007 Dec Curr Stem Cell Res Ther Expansion of umbilical cord blood for clinical transplantation Haylock DN, Nilsson SK.
2007 Dec Curr Stem Cell Res Ther Umbilical cord blood: a unique source of pluripotent
stem cells for regenerative medicine
Harris DT, Rogers I.
2007 Dec Exp Hematol The potential of umbilical cord blood multipotent stem cells
for nonhematopoietic tissue and cell regeneration
van de Ven C, Collins D, Bradley MB, Morris E, Cairo MS.
2007 May -Jun Acta Paediatr Taiwan Umbilical cord blood transplantation: application in pediatric patients Jaing TH.
2007 Nov Curr Opin Oncol Leukemia: cord blood for allogeneic stem cell transplantation Takahashi S.
2007 Sep Expert Opin Biol Ther The potential of cord blood stem cells for use in regenerative medicine Harris DT, Badowski M, Ahmad N, Gaballa MA.
2007 Dec Curr Opin Allergy Clin Immunol Cord blood stem cell transplantation in primary immune deficiencies Gennery AR, Cant AJ.
2007 Jan Pediatrics First report of autologous cord blood transplantation in the
treatment of a child with leukemia
Hayani A, Lampeter E, Viswanatha D, Morgan D, Salvi SN.
2007 May Pediatrics Autologous cord blood transplantation in a child with acute
lymphoblastic leukemia and central nervous system relapse
Urban C, Schwinger W, Benesch M, Sovinz P, Henze G, Greinix H.
2007 Curr Pharm Des Transplantation and other uses of human umbilical cord blood and stem cells Goldstein G, Toren A, Nagler A.
2007 Cell Transplant Umbilical cord blood research: current and future perspectives Newcomb JD, Sanberg PR, Klasko SK, Willing AE.
2007 Cytotherapy Immune reconstitution after unrelated cord blood transplantation Szabolcs P, Niedzwiecki D.
2007 May J Mol Cell Cardiol Umbilical cord blood stem cells: implications for cardiovascular
regenerative medicine
Goldberg JL, Laughlin MJ, Pompili VJ.
2007 Apr Br J Haematol Expanding the role of umbilical cord blood transplantation Brunstein CG, Setubal DC, Wagner JE.
2007 May Burns Stem cell strategies in burns care Burd A, Ahmed K, Lam S, Ayyappan T, Huang L.
2007 Jan Curr Vasc Pharmacol Do adult stem cells ameliorate the damaged myocardium?
Human cord blood as a potential source of stem cells
Furfaro EM, Gaballa MA.
2007 Mar Curr Opin Hematol Umbilical cord blood transplantation for myeloid malignancies Brunstein CG, Baker KS, Wagner JE.
2007 Mar Curr Opin Hematol Alternative donor transplantation in acute myeloid leukemia:
which source and when?
Zuckerman T, Rowe JM.
2007 Jan Bone Marrow Transplant Ex vivo expansion of umbilical cord blood stem cells for
transplantation: growing knowledge from the hematopoietic niche
Hofmeister CC, Zhang J, Knight KL, Le P, Stiff PJ.
2006 Mar Bone Marrow Transplant Allogeneic and autologous transplantation for haematological diseases,
solid tumours and immune disorders:
definitions and current practice in Europe
Ljungman P, Urbano-Ispizua A, Cavazzana-Calvo M, Demirer T, Dini G, Einsele H, Gratwohl A, et all
2006 Sep Curr Stem Cell Res Ther Advances in umbilical cord blood transplantation Ballen KK.
2006 Nov Regen Med Umbilical cord-derived stem cells for tissue therapy: current and future uses Madlambayan G, Rogers I.
2006 Stem Cell Rev Cord-blood mesenchymal stem cells and tissue engineering Cetrulo CL Jr.
2006 Nov Regen Med Stem cells in the umbilical cord Weiss ML, Troyer DL.
2006 Methods Enzymol Cord blood stem and progenitor cells Broxmeyer HE, Srour E, Orschell C, Ingram DA, Cooper S, Plett PA, Mead LE, Yoder MC.
2006 Nov Semin Reprod Med Stem cells from umbilical cord blood Sanchez-Ramos J.
2006 Nov Curr Med Res Opin The key role of adult stem cells: therapeutic perspectives Pessina A, Gribaldo L.
2006 Sep Aust Fam Physician Stem cells--a clinical update Tuch BE.
2006 Oct Vox Sang Cord blood transplantation for adults. Brunstein CG, Wagner JE.
2006 Jun Acta Med Croatica Umbilical cord blood as a source of stem cells Bojanic I, Golubic Cepulic B.
2006 Neurodegener Dis Neuronal differentiation of human umbilical cord blood
neural stem-like cell line
Buzanska L, Jurga M, Domanska-Janik K.
2006 Oct Curr Opin Immunol Double umbilical cord blood transplantation Majhail NS, Brunstein CG, Wagner JE.
2006 Apr Ann N Y Acad Sci Stem cells and tissue engineering: past, present, and future Polak JM, Bishop AE.
2006 Apr J Inherit Metab Dis Trends in haematopoietic cell transplantation for inborn errors of metabolism Boelens JJ.
2006 Jul Bone Marrow Transplant Adult umbilical cord blood transplantation: a comprehensive review Schoemans H, Theunissen K, Maertens J, Boogaerts M, Verfaillie C, Wagner J.
2006 Jun Hum Immunol Why cord blood? Rubinstein P.
2006 Feb J Assoc Physicians India Umbilical cord blood transplantation: newer trends Agarwal MB.
2006 Curr Med Chem Human umbilical cord blood biology, transplantation and plasticity Goldstein G, Toren A, Nagler A.
2006 Apr Med J Aust No longer a biological waste product: umbilical cord blood O'Brien TA, Tiedemann K, Vowels MR.
2006 Annu Rev Med Umbilical cord blood transplantation and banking Brunstein CG, Wagner JE.
2006 Jan Biol Blood Marrow Transplant Clinical use of umbilical cord blood hematopoietic stem cells Rocha V, Gluckman E; Eurocord and European Blood and Marrow Transplant Group.
2006 Jan Eur J Haematol Transplantation of umbilical cord blood-derived endothelial
progenitor cells: a promising method of therapeutic revascularisation
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2005 Mar -Apr Rev Invest Clin Hematopoietic stem-cell transplantation using
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2005 Oct J Med Assoc Thai Clinical use of cord blood for stem cell transplantation Vanichsetakul P.
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adult stem cells from umbilical cord and cord blood as alternative
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Jacobs VR, Niemeyer M, Gottschalk N, Schneider KT, Kiechle M, Oostendorp RA, Peschel C, H?nicka M, Lehle K, Birnbaum D, et all
2006 Dec Obstet Gynecol Umbilical cord stem cells Moise KJ Jr.
2005 Oct Z Geburtshilfe Neonatol Stem cell transplantation of umbilical chord blood from related
and non-related donors in children and adults--a review of
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2005 Nov Curr Oncol Rep Umbilical cord blood transplantation Petropoulos D, Chan KW.
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2005 Jun Ginekol Pol Umbilical cord blood--a perfect source of stem cells? Stojko R, Witek A.
2005 Cytotherapy Umbilical cord blood-derived cells for tissue repair K?rbling M, Robinson S, Estrov Z, Champlin R, Shpall E.
2005 Cytotherapy Human umbilical cord blood cells: a new alternative for myocardial repair? Leor J, Guetta E, Chouraqui P, Guetta V, Nagler A.
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2005 Cytotherapy Cord blood transplantation in adult patients Tse W, Laughlin M.
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2005 J Hepatobiliary Pancreat Surg Hepatocyte differentiation from embryonic
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2005 May Ann N Y Acad Sci Umbilical cord blood-derived stem cells and brain repair Sanberg PR, Willing AE, Garbuzova-Davis S, Saporta S, Liu G, Sanberg CD, Bickford PC, Klasko SK, El-Badri NS.
2005 May Hum Immunoly Cord blood immunology and stem cell transplantation Bradley MB, Cairo MS.
2004 Jul Curr Neurovasc Res Use of human umbilical cord blood (HUCB) cells to repair the damaged brain Newman MB, Emerich DF, Borlongan CV, Sanberg CD, Sanberg PR.
2004 Jul Curr Neurovasc Res Neural induction of adult bone marrow and umbilical cord stem cells Ortiz-Gonzalez XR, Keene CD, Verfaillie CM, Low WC.
2004 Nov Biol Blood Marrow Transplant The successful treatment of severe aplastic anemia with
autologous cord blood transplantation
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2004 Mar Expert Opin Biol Ther Cell therapies for type 1 diabetes mellitus Shamblott MJ, Clark GO.
2002 Apr Bone Marrow Transplant Allogeneic and autologous transplantation for haematological diseases,
solid tumours and immune disorders:
definitions and currenz practice in Europe
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2002 Nov Bone Marrow Transplant Autologous cord blood transplantation. A procedure with
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