Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases,
Immunopathology, and Cancer.
The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own.
The NIH Human Microbiome Project.
he Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource.
Metabolic endotoxemia with obesity: is it real and is it relevant?
Obesity is associated with metabolic derangements in multiple tissues, which contribute to the progression of insulin resistance and the metabolic syndrome.
Dysbiosis and the immune system
We categorize dysbiosis in conceptual terms and provide an overview of immunological associations; the causes and consequences of bacterial dysbiosis, and their involvement in the molecular aetiology of common diseases; and implications for the rational design of new therapeutic approaches.
Diet and microbiota in inflammatory bowel disease:
The gut in disharmony.
Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states.
Nutritional Management of Metabolic Endotoxemia:
A Clinical Review.
Diet-induced, metabolic endotoxemia is emerging as an important contributory factor to the development of a wide range of chronic diseases, including cardiometabolic, autoimmune, psychiatric, and neurodegenerative illnesses.
Mechanisms and consequences of intestinal
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota itself.
Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.
The human gastrointestinal tract digests food, absorbs nutrients, and plays important roles in maintaining metabolic homeostasis.
Gut Dysbiosis and Muscle Aging:
Searching for Novel Targets against
Advanced age is characterized by several changes, one of which is the impairment of the homeostasis of intestinal microbiota.
Composition and richness of the serum microbiome differ by age and link tosystemic inflammation.
Advanced age has been associated with alterations to the microbiome within the intestinal tract as well as intestinal permeability (i.e., “leaky gut”).
When human cells meet bacteria: Precision
medicine for cancers using the microbiota.
The human microbiota interacts with the host immune system in multiple ways to influence the development of diseases, including cancers; however, a detailed understanding of their relationship is unavailable.
Microbiome Research Is Becoming theKey to Better Understanding Healthand Nutrition.
The human microbiome has emerged as the crucial moderator in the interactions between food and our body.
Carcinogenesis as a Result of Multiple Inflammatory and Oxidative Hits: a Comprehensive Review from Tumor Microenvironment to Gut Microbiota.
Over the years, researchers tried to explain cancer pathogenesis by taking into consideration different factors, such as immune system, the genetic predisposition and environmental factors.
The Human Gut Microbiome – A Potential Controller
of Wellness and Disease.
Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota.
The gut microbiome and colorectal cancer:
A review of bacterial pathogenesis.
Colorectal cancer (CRC) is the third most common newly diagnosed cancer in both men and women in the Unites States.
Intestinal microbiota: a novel perspective
in colorectal cancer biotherapeutics.
It is believed that genetic factors, immune system dysfunction, chronic inflammation, and intestinal microbiota (IM) dysbiosis contribute to the pathogenesis of colorectal cancer (CRC).
Gut microbiota and aging.
The hypothesis of an important role of gut microbiota in maintaining physiological state into the gastrointestinal (GI) system is supported by qualitative and quantitative alteration of the intestinal flora in a number of physiological and pathological condition as shown in several studies.