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Exosome therapy is a regenerative treatment that delivers exosomes, the nano-sized vesicles that stem cells release to send repair signals, into the skin, scalp or joints to support collagen production, hair growth and tissue repair. Exosome treatment is cell-free: it carries the proteins, lipids and microRNAs of mesenchymal stem cells without injecting any living cells.
This guide comes from Bioscience Institute, a group of GMP-certified cell laboratories, biobanks and a clinic working since 2007 in San Marino, Rome, Dubai and Boston. It explains what exosomes are, how exosome therapy works, what it is used for, what results look like before and after, how many sessions are planned, the side effects and what drives the cost. For the full map of our regenerative treatments see stem cell and exosome treatments; for the two most requested areas go straight to exosome treatment for skin and exosome treatment for hair loss.
What is exosome therapy? The power of exosome therapy
Exosome therapy uses purified exosomes from mesenchymal stem cells (MSCs) as a biological signal: applied to a tissue, they instruct the local cells to repair, calm inflammation and rebuild their supporting matrix. At Bioscience Institute the exosomes come from adipose-derived mesenchymal stem cells (AD-MSCs), the stem cells found in fat tissue.
Exosomes are membrane-bound vesicles, typically ranging from 30 to 150 nm in size, that are secreted by various cell types, including mesenchymal stem cells. They play a crucial role in cell-to-cell communication by transferring proteins, lipids and nucleic acids (such as mRNA and microRNA) between cells. The cargo within exosomes can influence the behaviour and function of recipient cells, which makes them key players in many physiological and pathological processes.
Adipose-derived mesenchymal stem cell (AD-MSC) exosomes are the small extracellular vesicles released by adipose-derived mesenchymal stem cells. These stem cells are a type of multipotent stromal cell found in adipose (fat) tissue, and they have the ability to differentiate into various cell types, such as adipocytes, osteoblasts and chondrocytes.
AD-MSC exosomes have attracted significant interest in recent years because of their potential therapeutic applications. They have been found to possess regenerative, anti-inflammatory, angiogenic and immunomodulatory properties, which make them promising candidates for treating a wide range of conditions, including tissue injury, degenerative diseases and inflammatory disorders.
Some of the potential therapeutic applications of AD-MSC exosomes include:
Tissue repair and regeneration
They can promote cell proliferation, migration and differentiation, helping in the regeneration of damaged tissues such as skin, bone and cartilage.
Wound healing
AD-MSC exosomes can stimulate the formation of new blood vessels, reduce inflammation and promote tissue remodelling, which can enhance the wound healing process.
Anti-inflammatory and immunomodulatory effects
They can modulate immune cell functions, reduce inflammation and promote tissue repair, which is why they are studied in autoimmune and inflammatory diseases.
Neuroprotection
In preclinical research, AD-MSC exosomes have been found to protect neurons from damage and promote neural regeneration in models of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.
How exosome therapy works: mode of action
Exosome therapy works through cell-to-cell communication: the exosomes are taken up by the cells of the treated tissue and release their cargo, which changes how those cells behave. In practice this means more collagen and elastin from skin fibroblasts, a better-nourished hair follicle or a less inflamed joint.
Exosomes play crucial roles in intercellular communication and in the regulation of many physiological and pathological processes. Their mode of action can be described in five steps:
1. Biogenesis
Exosomes are formed through the inward budding of endosomal membranes, which results in the formation of multivesicular bodies (MVBs) containing intraluminal vesicles (ILVs). MVBs can either be degraded by fusing with lysosomes or released into the extracellular space by fusing with the plasma membrane.
2. Loading
Exosomes carry a diverse range of biomolecules, such as proteins, lipids and nucleic acids (including mRNA, miRNA and other non-coding RNAs). The specific cargo of exosomes depends on the cell type, its physiological state and environmental conditions.
3. Release
Exosomes are released from the parent cell into the extracellular environment through the fusion of MVBs with the plasma membrane. This process is facilitated by various proteins, such as Rab GTPases, SNAREs and ESCRT complexes.
4. Uptake by recipient cells
Exosomes can be taken up by recipient cells through several mechanisms, including direct fusion with the plasma membrane, endocytosis or receptor-mediated uptake. The specific uptake mechanism depends on the exosomal surface proteins and the recipient cell type.
5. Cargo delivery and functional effects
Once inside the recipient cell, the exosomal cargo (proteins, lipids and nucleic acids) is released into the cytoplasm and can exert various functional effects, such as modulation of gene expression, signalling pathways and cellular processes.
Overall, the mode of action of exosomes depends on biogenesis, loading, release, uptake and cargo delivery. By carrying biomolecules from one cell to another, exosomes take part in immune responses, tissue repair and many other processes in the body.
What this means in a treatment
MSC-derived exosomes act as biological messengers that deliver regenerative signals directly to target cells. In a treatment, three mechanisms matter most:
- Tissue regeneration: they stimulate cell proliferation, migration and differentiation to repair damaged tissue and restore normal function.
- Anti-inflammatory action: they modulate immune responses, reduce chronic inflammation and shift macrophages towards an anti-inflammatory state.
- Angiogenesis: they support the formation of new blood vessels and improve circulation, so the treated tissue receives more oxygen and nutrients.
What exosome treatment is used for
Exosome treatment is used mainly for skin rejuvenation, hair loss, scars and stretch marks, joint and tendon problems, sexual health, sports recovery and ageing. Each area has its own page; the summaries below explain what exosomes do there and link to the full guide.
Exosomes for skin and face
Exosomes can boost the skin's natural healing, especially when delivered deeply into the dermis, so the skin rebuilds itself from the inside out. Exosome facial rejuvenation has been reported to increase skin collagen in the treated areas by up to six-fold and elastin levels by up to 300%.
The face protocol is EXOSKIN. It targets fine lines, loss of firmness, dull texture, enlarged pores and uneven tone. Read the full guide to exosome treatment for skin, or the focused pages on exosomes for wrinkles and exosomes for skin ageing.
Exosomes for hair loss
Adipose-derived mesenchymal stem cell (ADMSC) exosomes have emerged as a treatment option for hair loss, owing to their regenerative and immunomodulatory properties. Several studies suggest that ADMSC exosomes may promote hair growth by acting on the cellular and molecular processes of the hair follicle: they can reactivate dormant follicles, prolong the growth (anagen) phase and improve scalp blood supply.
The hair protocol is EXOHAIR, delivered by scalp microinjections. Our guide to exosome treatment for hair loss covers which types of hair loss respond, and the page on stem cell hair loss treatment explains the cell-based alternative.
Exosomes for scars and stretch marks
Exosomes play essential roles in tissue regeneration. With a function similar to their parent cells, they are easier to store and transport, and they protect the bioactive substances they carry from adverse conditions such as changes in pH, high temperature and repeated freezing and thawing. For this reason exosome therapy may be safer and more efficient than PRP for scar remodelling.
On scars, exosomes support collagen remodelling, reduce redness and help regulate fibrosis, which matters for acne scars, surgical scars and stretch marks. Read more about exosomes for scars and stretch marks.
Exosomes for joints and orthopaedics
Exosome therapy for orthopaedic conditions promotes tissue repair and regeneration in osteoarthritis, cartilage degeneration and cartilage injuries, tendon and ligament injuries, tendonitis and tendinopathy, bone fractures and non-unions, avascular necrosis, and other conditions with inflammation, tissue damage and loss of function.
The joint protocol is EXOJOINTS, given by injection. See exosome therapy for knees and joints, our cell-based ORTHOSKILL osteoarticular regeneration and the guide to stem cell therapy for knees.
Exosomes for erectile dysfunction
Exosomes derived from mesenchymal stem cells (MSCs) have been studied as a therapeutic option for erectile dysfunction (ED). MSC-derived exosomes contain growth factors, cytokines and microRNAs that can act on the underlying causes of ED: the health of the erectile tissue and of its blood vessels.
The protocol is EXOMALE, delivered by intracavernosal injections on an outpatient basis. Read the full guide to exosomes for erectile dysfunction.
Exosomes for vaginal rejuvenation
Adipose-derived mesenchymal stem cell (AD-MSC) exosomes may support vaginal rejuvenation thanks to their regenerative, anti-inflammatory and angiogenic properties. They are considered for vaginal dryness and atrophy, loss of elasticity after childbirth or menopause, and mild urinary incontinence.
The protocol is EXOFEMALE, applied topically or by minimally invasive injection. See exosome therapy for vaginal rejuvenation.
Exosomes for body performance and sports recovery
Mesenchymal stem cell (MSC) exosomes are studied for sports performance and recovery because of their regenerative, immunomodulatory and anti-inflammatory properties. As natural carriers of bioactive molecules, they can support muscle recovery, joint and tendon health and a faster return to training after injury.
The protocol is EXOSPORT, given by targeted injections into muscles, joints or tendons, or intravenously. Read more about exosomes for body performance and exosomes for sports performance.
Exosomes for anti-ageing
Mesenchymal stem cell (MSC) exosomes are a therapeutic option for age-related changes and overall vitality. Their regenerative, immunomodulatory and anti-inflammatory properties act on what is often called "inflammaging", the low-grade chronic inflammation that accompanies ageing.
The protocol is EXOAGEING, which can combine intravenous infusion, targeted injections and topical application depending on the goals. See anti-aging exosome therapy.
Exosome therapy before and after: results and timeline
Exosome therapy results build gradually, because exosomes do not fill or freeze the tissue: they trigger the body's own repair, and new collagen, new hair and repaired cartilage take time to form. Before and after photos are therefore taken weeks to months apart, not on the day of the session.
Skin and face
After a skin session there may be a short-lived glow from hydration and the microneedling itself. The real change, firmer skin, finer texture, smaller-looking pores and softer lines, follows the collagen remodelling cycle and becomes visible progressively over the following weeks. The fairest comparison is the same angle and the same light, before the first session and after the course.
Hair
Hair follicles work in slow growth cycles, so hair results are judged over months. The first signs are usually less shedding and finer new hairs, followed by more density. Standardised scalp photos, taken at each visit, are the most reliable way to see the before and after.
Joints, scars and sexual health
For joints the outcome is measured in pain, stiffness and function rather than in photos. Scars and stretch marks improve in texture and colour as the dermis remodels. For erectile function and intimate health the physician agrees in advance how progress will be assessed.
How many exosome sessions do you need?
The number of exosome sessions depends on the area, how advanced the problem is and how the exosomes are delivered. Skin and hair protocols are usually planned as a course of sessions followed by maintenance, while joint and sexual health protocols are planned after a medical assessment and, for joints, imaging.
The physician sets the plan at the consultation and adjusts it to the response after the first sessions. The table summarises how each area is treated.
| Area | Protocol | How exosomes are delivered | What the session plan depends on |
|---|---|---|---|
| Face and skin | EXOSKIN | Microinjection, mesotherapy, cannula or with microneedling | Skin quality, depth of lines, combination with laser or peels |
| Scars and stretch marks | EXOSKIN | Microinjection or microneedling over the scar | Type of scar (atrophic, hypertrophic, keloid) and its age |
| Hair loss | EXOHAIR | Scalp microinjections | Type and stage of hair loss |
| Joints and tendons | EXOJOINTS | Injection into or around the joint or tendon | Diagnosis, imaging, degree of degeneration |
| Erectile dysfunction | EXOMALE | Intracavernosal injection | Cause and severity of ED |
| Vaginal rejuvenation | EXOFEMALE | Topical application or minimally invasive injection | Symptoms: dryness, laxity, incontinence |
| Sports recovery | EXOSPORT | Targeted injection or intravenous | Injury, training load, goals |
| Anti-ageing | EXOAGEING | Intravenous, targeted injection or topical | General health and goals |
Is exosome therapy safe? Side effects
Exosome therapy is generally well tolerated when the product is made and tested to pharmaceutical standards: exosomes are cell-free, have low immunogenicity and carry a lower risk of the complications associated with live cell therapies. The most common side effects come from the procedure itself: temporary redness, swelling, tenderness or small bruises where the needle or microneedling device was used.
The real risk lies in product quality. In December 2019 the US Food and Drug Administration (FDA) issued a public safety notification after serious adverse events in patients treated with unapproved products marketed as containing exosomes, and the FDA lists no approved exosome product. That is why the source of the exosomes, the laboratory that produced them and its sterility and endotoxin testing matter as much as the treatment itself.
Who should not have exosome treatment
Candidates should be in good general health, with no active infection at the treatment site and no uncontrolled medical condition. The physician reviews your history, medicines and any previous treatments before agreeing a plan. Our page on whether stem cell therapy is legal in the UAE explains who regulates these treatments, and our checklist on how to choose a stem cell clinic lists the questions to ask.
Exosome therapy cost: what drives the price
Exosome therapy cost depends on the area treated, the number of sessions, the delivery method and the quality and dose of the exosome product. A single skin or hair session costs less than a joint protocol or an intravenous programme, and a course of sessions costs more than one visit.
The main price factors are:
- The product: the cell source, how the exosomes are isolated and tested, and the dose per session.
- The area and the method: face, scalp, joint, intimate area or intravenous; with or without microneedling or image guidance.
- The number of sessions and any maintenance sessions.
- Medical work around the session: consultation, imaging or tests where needed, follow-up visits.
We quote a price after the consultation, once the protocol is defined. Our guide to stem cell therapy cost explains what a quote should include and how to compare clinics.
Exosomes vs PRP and vs stem cells
Exosomes, PRP and stem cells are three different tools: PRP concentrates growth factors from your own blood platelets, stem cell therapy uses living cells, and exosome therapy uses the signalling vesicles of stem cells without the cells. Which one fits depends on the problem, the area and whether a procedure on your own tissue is practical.
Exosomes vs PRP
PRP (platelet-rich plasma) is prepared from a sample of your blood on the day of treatment, so its strength varies from person to person and from day to day. Exosomes are prepared in the laboratory from stem cells, carry a wider set of signals (proteins, lipids, microRNAs) and need no blood draw. Our comparison of exosomes vs PRP covers results, sessions and cost side by side.
Exosomes vs stem cells
Stem cell therapy relies on living cells that must survive, settle and work in the tissue; it needs careful handling and, for your own cells, a harvest procedure. Exosome therapy uses cell-free vesicles that are more stable, easier to store and act without engraftment. Read exosomes vs stem cells and, for the third pair, stem cells vs PRP.
Differences between (ADMSC) exosomes and exosomes derived from other sources
Difference between ADMSC exosomes and exosomes derived from other cells
Exosomes are extracellular vesicles secreted by various cell types, including mesenchymal stem cells (MSCs). The primary differences between adipose-derived mesenchymal stem cell (ADMSC) exosomes and exosomes derived from other sources come from their origin, composition and functional properties.
1. Source of origin
ADMSC exosomes are derived from mesenchymal stem cells found in adipose tissue, while exosomes from other sources can be isolated from different cell types, tissues or biofluids. For example, exosomes can be derived from bone marrow-derived MSCs, umbilical cord-derived MSCs, or other cell types such as cancer cells, immune cells or endothelial cells.
2. Molecular composition
Exosomes derived from different sources may have unique protein, lipid and nucleic acid compositions that reflect their parent cell type. These variations in composition can result in distinct biological effects when they interact with recipient cells. For example, ADMSC exosomes might contain specific proteins or microRNAs involved in adipogenesis, while exosomes from bone marrow-derived MSCs might have different molecular contents relevant to haematopoiesis.
3. Functional properties
Because of differences in their molecular composition, exosomes from various sources can exhibit unique functional properties. ADMSC exosomes have been reported to possess immunomodulatory, anti-inflammatory and pro-angiogenic properties. In contrast, exosomes from other sources may show different functional properties depending on their cellular origin, such as tumour-promoting effects in the case of exosomes derived from cancer cells, or immune response modulation in the case of exosomes derived from immune cells.
4. Therapeutic applications
The unique properties of exosomes from different sources might make them more suitable for specific therapeutic applications. For example, ADMSC exosomes have demonstrated potential in wound healing, tissue repair and the treatment of conditions such as cardiovascular disorders, whereas exosomes from other sources might have different therapeutic potential based on their unique properties.
In conclusion, the main differences between ADMSC exosomes and exosomes derived from other sources lie in their origin, molecular composition, functional properties and potential therapeutic applications. The choice of exosome source depends on the specific research or clinical application being considered.
Difference between stem cell and vegetable sources
Exosomes have the therapeutic properties of their source: obtained from stem cells, they mimic the regenerative properties of stem cells; obtained from plants, they carry the properties of plants. Exosomes derived from adipose-derived mesenchymal stem cells (ADMSCs) and those derived from plant (vegetal) sources differ in origin, composition, biogenesis and potential applications. Here are the key differences between the two types:
1. Origin
ADMSC exosomes are derived from mesenchymal stem cells found in the adipose tissue of mammals, including humans. In contrast, plant-derived exosomes (also known as plant-derived extracellular vesicles) are secreted by plant cells, such as those of fruits, vegetables and other plant tissues.
2. Biogenesis
The biogenesis of exosomes in animal cells, including ADMSCs, occurs through the endosomal sorting complex required for transport (ESCRT) pathway or ESCRT-independent mechanisms, resulting in the release of exosomes through multivesicular bodies (MVBs) fusing with the plasma membrane. Plant-derived exosomes have a distinct biogenesis process that is not fully understood but may involve unique mechanisms related to the plant endomembrane system.
3. Composition
ADMSC exosomes contain proteins, lipids and nucleic acids (such as microRNAs) that are specific to their mammalian origin and reflect the characteristics of their parent cells. Plant-derived exosomes also contain proteins, lipids and nucleic acids, but their composition is specific to their plant source and can differ significantly from animal-derived exosomes.
4. Immunogenicity
ADMSC exosomes have low immunogenicity and can modulate immune responses in mammals, which makes them suitable for potential therapeutic applications in humans. Plant-derived exosomes, because of their non-mammalian origin, may have higher immunogenicity when administered to humans or other mammals, which could limit their therapeutic potential.
5. Functional properties and potential applications
ADMSC exosomes have demonstrated potential in various therapeutic applications, such as wound healing, tissue repair and the treatment of cardiovascular and neurological disorders. Plant-derived exosomes have been studied for their potential in agriculture, such as enhancing plant growth, stress resistance and inter-kingdom communication. There is growing interest in plant-derived exosomes for human health, but more research is needed to understand their applications and any associated risks.
In summary, the main differences between ADMSC exosomes and plant-derived exosomes are their origin, composition, biogenesis, immunogenicity and potential applications. The choice of exosome source depends on the specific research or application goals.
Difference between fresh and lyophilised exosomes
The main difference between fresh adipose-derived mesenchymal stem cell (ADMSC) exosomes and lyophilised (freeze-dried) exosomes lies in their processing and storage. Both originate from the same source, but their preservation methods have distinct implications for their properties, stability and potential applications.
1. Processing
Fresh ADMSC exosomes are isolated from the culture medium of adipose-derived mesenchymal stem cells and are typically suspended in a suitable buffer solution. Lyophilised exosomes undergo a freeze-drying process in which they are first frozen and then subjected to a vacuum to remove water, resulting in a dry, stable product.
2. Stability and shelf life
Lyophilised exosomes are generally more stable and have a longer shelf life than fresh exosomes. Freeze-drying removes water, which helps prevent the degradation of biological molecules and protects the exosomes from temperature fluctuations during storage and transport. Fresh exosomes must be stored at low temperatures (usually -80°C) to keep their integrity and biological activity, and their shelf life can be limited.
3. Reconstitution
Before use, lyophilised exosomes need to be reconstituted by adding an appropriate buffer solution to reach the desired concentration. This step is not required for fresh exosomes, which are already suspended in a buffer solution.
4. Potential impact on biological activity
Lyophilisation is intended to preserve the exosomes' biological activity, but the freeze-drying process may affect their structure, composition or function. It is essential to optimise the process and include cryoprotectants to minimise any negative impact. Fresh exosomes are not lyophilised, and their biological activity is typically maintained as long as they are stored and handled properly.
5. Transportation and storage
Lyophilised exosomes are easier to transport and store, as they are stable at room temperature or 4°C for short periods and can be stored long-term at -20°C or -80°C. Fresh exosomes require storage at -80°C and need to be transported on dry ice to maintain their stability and integrity.
In summary, the primary differences between fresh ADMSC exosomes and lyophilised exosomes are their processing, stability, shelf life, reconstitution requirements and potential impact on biological activity. The choice depends on the specific application and on the logistics of storage and transport.
Why ADMSC exosomes
Adipose-derived mesenchymal stem cell (ADMSC) exosomes are increasingly used in research and therapy because of their unique properties and potential benefits. Here are the reasons why researchers and clinicians choose them:
1. Source abundance
Adipose tissue is abundant and easily accessible in the human body, which makes it a convenient source for isolating mesenchymal stem cells.
2. Minimally invasive extraction
ADMSCs can be obtained through minimally invasive procedures, such as liposuction, which has fewer complications and faster recovery than other methods of stem cell extraction.
3. Immunomodulatory properties
ADMSC exosomes have been found to exhibit immunomodulatory properties, which can reduce inflammation and improve the overall immune response in the recipient.
4. Tissue regeneration and repair
ADMSC exosomes have shown promising results in promoting tissue regeneration and repair, including the promotion of angiogenesis, the modulation of immune responses and the stimulation of cell proliferation and differentiation.
5. Potential therapeutic applications
ADMSC exosomes have demonstrated potential in wound healing, tissue regeneration and the treatment of various diseases, including cardiovascular diseases, neurological disorders and autoimmune diseases.
6. Low immunogenicity
Exosomes derived from ADMSCs have been reported to have low immunogenicity, meaning they are less likely to trigger an immune response in the recipient, which makes them suitable for allogeneic use.
7. Cell-free therapy
As exosomes are cell-free, they carry a lower risk of tumour formation and other complications associated with stem cell therapies. This makes them an attractive alternative in regenerative medicine.
8. Ease of storage and transportation
Exosomes can be stored and transported more easily than live cells, which simplifies their use in research and clinical practice.
Our exosome treatment portfolio
Bioscience Institute has developed a range of exosome-based regenerative protocols, each designed for a specific health or aesthetic concern. They all use MSC-derived exosomes; what changes is the dose, the delivery method and the schedule.
EXOSKIN: advanced skin rejuvenation
EXOSKIN uses MSC exosomes to restore skin quality from the cellular level. It stimulates fibroblast activity, promotes collagen and elastin synthesis and reduces the oxidative stress that contributes to skin ageing. Expected benefits: fewer fine lines and wrinkles, better elasticity and firmness, better hydration and texture, fewer age spots and faster healing after aesthetic procedures. It suits people seeking non-surgical facial rejuvenation, scar and stretch mark treatment or better overall skin quality. Discover EXOSKIN.
EXOHAIR: hair regeneration therapy
EXOHAIR targets hair loss at the follicle. MSC exosomes activate dormant hair follicle stem cells, promote angiogenesis for better nutrient delivery and modulate the inflammation that contributes to hair loss. Expected benefits: reactivated follicles, a longer growth phase, better scalp vascularisation and thicker, stronger hair. It suits androgenetic alopecia, alopecia areata and people looking for a non-surgical alternative to hair transplantation. Discover EXOHAIR.
EXOJOINTS: regenerative joint therapy
EXOJOINTS addresses osteoarthritis and joint degeneration by promoting cartilage repair, reducing joint inflammation, modulating immune responses and stimulating chondrocyte activity. Expected benefits: support for cartilage regeneration, less inflammation and pain, better mobility and a slower progression of degenerative joint disease. It suits patients with osteoarthritis, sports injuries or degenerative joint conditions who want to avoid or delay surgery. Discover EXOJOINTS.
EXOMALE: erectile function restoration
EXOMALE is a regenerative approach to erectile dysfunction that promotes tissue repair, improves vascular function and penile blood flow, and works on the underlying causes rather than on symptoms only. Expected benefits: better erectile quality, better penile vascular health and less dependence on ongoing medication. It suits men with erectile dysfunction or Peyronie's disease and men looking for an alternative to medicines. Discover EXOMALE.
EXOFEMALE: vaginal rejuvenation therapy
EXOFEMALE is a non-surgical treatment that promotes tissue regeneration in the vaginal area, for changes due to childbirth, menopause or ageing. Expected benefits: better tissue elasticity, better natural lubrication, fewer symptoms of vaginal atrophy, better urinary continence and sensation. It suits postpartum and postmenopausal women and anyone with vaginal dryness, laxity or mild urinary incontinence. Discover EXOFEMALE.
EXOSPORT: performance and recovery
EXOSPORT is designed for athletes and active people who want faster recovery and better resilience. MSC exosomes support muscle regeneration, reduce exercise-induced inflammation and optimise tissue repair. Expected benefits: faster recovery after exercise, less soreness, better joint and tendon health and a faster return to training after injury. It suits professional and amateur athletes and anyone recovering from a sports injury. Discover EXOSPORT.
EXOAGEING: comprehensive anti-ageing therapy
EXOAGEING addresses several aspects of ageing at once with a systemic exosome protocol aimed at skin, joints, muscles, cognitive function and metabolic health. Expected benefits: better skin appearance and vitality, better joint and muscle function, support for cardiovascular and metabolic health and less "inflammaging". It suits adults with several age-related concerns who want a coordinated plan. Discover EXOAGEING.
For home care between sessions, the topical XOLINE line brings exosomes into serums and creams for the face and scalp: see exosome cosmetics.
Exosome therapy procedure and quality control
The exosomes we use are extracted from human mesenchymal stem cells and thoroughly tested for quality and quantity. They contain lipids, messenger RNA, cytokines and proteins, and are administered according to the specialist's recommendation, by microinjection, mesotherapy, cannula, local injection or infusion depending on the area.
Before any procedure, every product goes through a strict screening process that certifies sterility, safety for use and endotoxin testing. Our standards behind every treatment:
- GMP-certified production: exosomes are produced in laboratories that follow Good Manufacturing Practice (GMP) standards.
- Batch quality control: every batch is tested for sterility, endotoxins, potency and purity before clinical use.
- Personalised protocols: the physician designs the plan around your condition, goals and medical history.
- Scientific experience: the group has worked in cell processing, biobanking and regenerative medicine since 2007.
- Follow-up: from the first consultation through treatment and follow-up visits, one team coordinates your care.
Clinical applications of exosomes in research
Beyond aesthetic and regenerative treatments, exosomes are being explored as therapeutic agents for a variety of clinical indications. The main research areas are:
Cancer: exosomes are investigated as a delivery system for anti-cancer drugs, or as a way to stimulate the immune system to recognise and attack cancer cells.
Regenerative medicine: exosomes are studied for tissue repair in conditions such as cardiovascular disease, neurological disorders and bone and cartilage defects.
Inflammatory and autoimmune disorders: thanks to their immunomodulatory effects, exosomes are studied in conditions such as rheumatoid arthritis and multiple sclerosis.
Infectious diseases: exosomes are investigated as carriers of antiviral or antimicrobial agents, or as a way to stimulate the immune response to infection.
Request exosome therapy: what happens at the consultation
Exosome therapy starts with a free consultation with one of our specialists. You describe the problem and your goals; the physician reviews your medical history, previous treatments and any tests or imaging, and tells you whether exosome treatment is suitable or whether another option, such as PRP or a stem cell procedure, fits better.
If exosome therapy is suitable, you receive a written plan: the protocol, the delivery method, the number of sessions, what to expect before and after, and the cost. You can then take your time to decide.
FAQ
What is exosome therapy?
Exosome therapy is a regenerative treatment that delivers exosomes, the tiny vesicles stem cells use to send repair signals, into the skin, scalp or joints. It supports collagen production, hair growth and tissue repair without injecting living cells.
Does exosome therapy work?
Exosomes carry growth factors, proteins and microRNAs that stimulate repair, collagen synthesis and follicle activity, and research on skin, hair and joints is promising. Results vary with the area, the severity of the problem and the quality of the product, so the physician tells you at the consultation what is realistic in your case.
How long does it take to see results from exosome therapy?
Results build gradually because exosomes trigger the body's own repair. Skin changes appear progressively over the weeks after a session, while hair results are judged over months because follicles grow in slow cycles.
How many exosome sessions will I need?
It depends on the area, how advanced the problem is and the delivery method. Skin and hair are usually treated with a course of sessions and maintenance, while joint and sexual health protocols are planned after a medical assessment.
Is exosome therapy safe?
Exosome therapy is generally well tolerated when the product is produced and tested to GMP standards, because exosomes are cell-free and have low immunogenicity. The usual side effects are temporary redness, swelling or small bruises at the treated site.
Are exosomes cancerous?
Exosomes contain no cells, so they carry a lower risk of tumour formation than live cell therapies. Their effect depends on their source: exosomes from cancer cells can promote tumours, which is why only exosomes from tested mesenchymal stem cells are used for treatment.
Is exosome therapy FDA approved?
No. The US FDA lists no approved exosome product and has warned consumers about unapproved stem cell and exosome products. What matters for you is the product itself, so ask any clinic which laboratory made it and how each batch was tested.
How much does exosome therapy cost?
The cost depends on the area treated, the number of sessions, the delivery method and the exosome product. We quote a price after the consultation, once the protocol is defined.
Is exosome therapy better than PRP?
Exosomes carry a wider set of regenerative signals than PRP, need no blood draw and have a consistent, laboratory-tested quality, while PRP depends on your own platelets on the day. PRP remains a simple option for some patients, and the two can be combined.
What is the difference between exosomes and stem cells?
Stem cell therapy uses living cells that must survive and work in the tissue, while exosome therapy uses only the signalling vesicles those cells release. Exosomes are cell-free, more stable and easier to store, and act without engraftment.
Can exosomes regrow hair?
Exosomes can reactivate dormant follicles, prolong the growth phase and improve scalp blood supply, which can reduce shedding and increase density in suitable types of hair loss. Follicles that have disappeared completely cannot be revived.
Is there downtime after exosome treatment?
Exosome treatment is performed on an outpatient basis with minimal downtime, and most people return to normal activities quickly. After microneedling or facial injections, the skin can stay red or slightly swollen for a short time.
Scientific content reviewed by the Bioscience Institute Scientific Board. · Last updated
The information on this page is for general education and does not replace a consultation with a physician.
