Human Umbilical Cord Mesenchymal Stem Cell Transplantation for the Treatment of Chronic Discogenic Low Back Pain.
Chronic low back pain is one of the major causes of disability and thus has a major socioeconomic impact.
Pancreatic Cancer in Chronic Pancreatitis
Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer.
Immunoregulation of Bone Marrow-Derived Mesenchymal Stem Cells on the Chronic Cigarette Smoking-Induced Lung Inflammation in Rats.
mpact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood.
Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and
One-Way Endobronchial Valve Placement
in Patients with Pulmonary Emphysema:
A Phase I Clinical Trial
One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients.
Clinical observation of umbilical cord mesenchymal stem cell treatment of
severe idiopathic pulmonary fibrosis:
A case report
Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis.
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the
role of nutrition.
Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions.
Mesenchymal stromal cell infusion
modulates systemic immunological responses
A phase I pilot study
Mesenchymal stromal cell infusion may provide an alternative immune-based therapeutic option for COPD patients
A phase I study for intravenous autologous mesenchymal stromal cell administration
to patients with severe emphysema
Background: Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema.
Mesenchymal stromal cell infusion may provide an alternative immune-based therapeutic option for
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route.
Mesenchymal stromal cells: a novel
therapy for the treatment of chronic
obstructive pulmonary disease?
COPD is characterised by tissue destruction and inflammation.
Autologous Stromal Vascular Fraction in
the Intravenous Treatment of End-Stage
Chronic Obstructive Pulmonary Disease:
A Phase I Trial of Safety and Tolerability
Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treat- ment exists capable of either reversing or even interrupting its course.
Clinical Application of Mesenchymal Stem
Cell-Derived Extracellular Vesicle-Based
Therapeutics for Inflammatory LungDiseases
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication.
Therapeutic Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal
characteristics and the ability
to differentiate into
Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal characteristics and the ability to differentiate into tissue-specific cells.
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.
Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints.