2009 January
Exercise as a Mean to Control Low-Grade Systemic Inflammation.
Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide.
2012 September
Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets
Aging is a multifactorial process that depends on diverse molecular and cellular mechanisms, such as genome maintenance and inflammation.
2013 January
Causes and consequences of low grade endotoxemia and inflammatory diseases.
Increasing clinical observations reveal that persistent low-grade inflammation is associated with the pathogenesis of severe chronic diseases such as atherosclerosis, diabetes, and aging-related neurological diseases.
2013 March
Cytokine Levels in the Serum of Healthy Subjects.
Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response.
2013 April
Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial.
Chronic inflammation is hypothesized to influence prostate cancer development, although a definitive link has not been established.
2014 April
Peripheral inflammation is associated with remote global gene expression changes in the brain.
Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur.
2014 November
Human Umbilical Cord Mesenchymal Stem Cell Transplantation for the Treatment of Chronic Discogenic Low Back Pain.
Chronic low back pain is one of the major causes of disability and thus has a major socioeconomic impact.
2015 January
Pancreatic Cancer in Chronic Pancreatitis
Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer.
2015 April
Inflammation-induced lymphangiogenesis and lymphatic dysfunction.
The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking.
2015 September
Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Chronic inflammation contributes to cancer development via multiple mechanisms.
2015 October
Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia.
Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others.
2015 October
Fatigue in chronic inflammation - A link to pain pathways
Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases.
2015 October
Immunoregulation of Bone Marrow-Derived Mesenchymal Stem Cells on the Chronic Cigarette Smoking-Induced Lung Inflammation in Rats.
mpact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood.
2015 November
Additive Contributions of Childhood Adversity and Recent Stressors to Inflammation at Midlife: Findings from the MIDUS Study.
We sought to examine the joint contributions of self-reported adverse childhood experiences (ACEs) and recent life events (RLEs) to inflammation at midlife, by testing three competing theoretical models: stress generation, stress accumulation, and early-life stress sensitization.
2016 January
The role of systemic inflammation linking maternal
body mass index to neurodevelopment in
children Inflammation and
Children of obese mothers are at increased risk of developmental adversities.
2016 May
From inflammation to cancer.
The participation of inflammation in the progression of cancer for many years have been the subject of research.
2016 November
GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation.
Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells.
2016 December
Insights into the Role and Interdependence of
Oxidative Stress and Inflammation in Liver
The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades.
2017 March
Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and
One-Way Endobronchial Valve Placement
in Patients with Pulmonary Emphysema:
A Phase I Clinical Trial
One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients.
2017 April
Age-Associated Microbial Dysbiosis Promotes
Intestinal Permeability, Systemic Inflammation,
and Macrophage Dysfunction.
Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated.
2017 April
Age-Associated Microbial Dysbiosis Promotes
Intestinal Permeability, Systemic Inflammation,
and Macrophage Dysfunction.
Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated.
2017 May
Clinical observation of umbilical cord mesenchymal stem cell treatment of
severe idiopathic pulmonary fibrosis:
A case report
Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis.
2017 August
Diet and microbiota in inflammatory bowel disease:
The gut in disharmony.
Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states.
2017 August
Allogeneic Mesenchymal Stem Cells as a Treatment
for Aging Frailty.
Advancing age is associated with a reduction in physical and mental functional capacity, and chronic inflammation is a major factor contributing to this decline.
2017 October
Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes.
Exercise physiology research has identified individual biomarkers for assessing health, performance, and recovery during exercise training. However, there are few recommendations for biomarker panels for tracking changes in individuals participating in physical activity and exercise training programs.
2017 October
Allogeneic Mesenchymal Stem Cells Ameliorate
Aging Frailty: A Phase II Randomized,
Double-Blind, Placebo-Controlled Clinical Trial.
Frailty confers an increased vulnerability to adverse health outcomes and mortality in response to stressors. The frailty syndrome is driven mostly by biological aging processes that include inflammation and stem cell dysfunction, as opposed to chronological aging
2017 November
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the
role of nutrition.
Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions.
2017 December
Long-Term Measurements of Human Inflammatory Cytokines Reveal Complex Baseline Variations
between Individuals.
This paper describes results from a 14-week study of healthy human subjects using ultrasensitive single-molecule array (Simoa) assays to measure both intra and intersubject variation of 15 cytokines.
2018 January
Mesenchymal stromal cell infusion
modulates systemic immunological responses
in stable
COPD patients:
A phase I pilot study
Mesenchymal stromal cell infusion may provide an alternative immune-based therapeutic option for COPD patients
2018 January
A phase I study for intravenous autologous mesenchymal stromal cell administration
to patients with severe emphysema
Background: Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema.
2018 January
Mesenchymal stromal cell infusion may provide an alternative immune-based therapeutic option for
COPD patients
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route.
2018 April
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines.
Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging.
2018 April
Mesenchymal stromal cells: a novel
therapy for the treatment of chronic
obstructive pulmonary disease?
COPD is characterised by tissue destruction and inflammation.
2018 April
Autologous Stromal Vascular Fraction in
the Intravenous Treatment of End-Stage
Chronic Obstructive Pulmonary Disease:
A Phase I Trial of Safety and Tolerability
Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treat- ment exists capable of either reversing or even interrupting its course.
2018 May
Gut, Microbiome, and Brain Regulatory Axis:
Relevance to Neurodegenerative and Psychiatric
It has become apparent that the molecular and biochemical integrity of interactive families, genera, and species of human gut microflora is critically linked to maintaining complex metabolic and behavioral processes mediated by peripheral organ systems and central nervous system neuronal groupings.
2018 June
Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases.
In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in the gut. Parkinson’s disease (PD) is the most intensively studied neurodegenerative disease in this context.
2018 July
Microbiome in the Gut-Skin Axis in Atopic Dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a drastic impact on pediatric health.
2018 November
Clinical Application of Mesenchymal Stem
Cell-Derived Extracellular Vesicle-Based
Therapeutics for Inflammatory LungDiseases
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication.
2018 November
A comparison of biofluid cytokine markers across platform technologies: T Correspondence or divergence?
Quantification of biofluid cytokines is a rapidly growing area of translational research.
2018 November
Therapeutic Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal
characteristics and the ability
to differentiate into
tissue-specific cells.
Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal characteristics and the ability to differentiate into tissue-specific cells.
2018 November
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.
Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints.