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2009 January Exercise as a Mean to Control Low-Grade Systemic Inflammation. Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. READ

2012 September Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance MeetsInflammation. Aging is a multifactorial process that depends on diverse molecular and cellular mechanisms, such as genome maintenance and inflammation. READ

2013 January Causes and consequences of low grade endotoxemia and inflammatory diseases. Increasing clinical observations reveal that persistent low-grade inflammation is associated with the pathogenesis of severe chronic diseases such as atherosclerosis, diabetes, and aging-related neurological diseases. READ

2013 March Cytokine Levels in the Serum of Healthy Subjects. Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. READ

2013 April Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial. Chronic inflammation is hypothesized to influence prostate cancer development, although a definitive link has not been established. READ

2014 April Peripheral inflammation is associated with remote global gene expression changes in the brain. Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur. READ

2014 November Human Umbilical Cord Mesenchymal Stem Cell Transplantation for the Treatment of Chronic Discogenic Low Back Pain. Chronic low back pain is one of the major causes of disability and thus has a major socioeconomic impact. READ

2015 January Pancreatic Cancer in Chronic Pancreatitis Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. READ

2015 April Inflammation-induced lymphangiogenesis and lymphatic dysfunction. The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. READ

2015 September Immunosuppression associated with chronic inflammation in the tumor microenvironment. Chronic inflammation contributes to cancer development via multiple mechanisms. READ

2015 October Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia. Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others. READ

2015 October Fatigue in chronic inflammation - A link to pain pathways Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. READ

2015 October Immunoregulation of Bone Marrow-Derived Mesenchymal Stem Cells on the Chronic Cigarette Smoking-Induced Lung Inflammation in Rats. mpact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood. READ

2015 November Additive Contributions of Childhood Adversity and Recent Stressors to Inflammation at Midlife: Findings from the MIDUS Study. We sought to examine the joint contributions of self-reported adverse childhood experiences (ACEs) and recent life events (RLEs) to inflammation at midlife, by testing three competing theoretical models: stress generation, stress accumulation, and early-life stress sensitization. READ

2016 January The role of systemic inflammation linking maternalbody mass index to neurodevelopment inchildren Inflammation andneurodevelopment. Children of obese mothers are at increased risk of developmental adversities. READ

2016 May From inflammation to cancer. The participation of inflammation in the progression of cancer for many years have been the subject of research. READ

2016 November GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. READ

2016 December Insights into the Role and Interdependence ofOxidative Stress and Inflammation in LiverDiseases. The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. READ

2017 March Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy andOne-Way Endobronchial Valve Placementin Patients with Pulmonary Emphysema:A Phase I Clinical Trial One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients. READ

2017 April Age-Associated Microbial Dysbiosis PromotesIntestinal Permeability, Systemic Inflammation,and Macrophage Dysfunction. Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated. READ

2017 May Clinical observation of umbilical cord mesenchymal stem cell treatment ofsevere idiopathic pulmonary fibrosis:A case report Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis. READ

2017 August Diet and microbiota in inflammatory bowel disease:The gut in disharmony. Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. READ

2017 August Allogeneic Mesenchymal Stem Cells as a Treatmentfor Aging Frailty. Advancing age is associated with a reduction in physical and mental functional capacity, and chronic inflammation is a major factor contributing to this decline. READ

2017 October Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes. Exercise physiology research has identified individual biomarkers for assessing health, performance, and recovery during exercise training. However, there are few recommendations for biomarker panels for tracking changes in individuals participating in physical activity and exercise training programs. READ

2017 October Allogeneic Mesenchymal Stem Cells AmeliorateAging Frailty: A Phase II Randomized,Double-Blind, Placebo-Controlled Clinical Trial. Frailty confers an increased vulnerability to adverse health outcomes and mortality in response to stressors. The frailty syndrome is driven mostly by biological aging processes that include inflammation and stem cell dysfunction, as opposed to chronological aging READ

2017 November Health relevance of the modification of low grade inflammation in ageing (inflammageing) and therole of nutrition. Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions. READ

2017 December Long-Term Measurements of Human Inflammatory Cytokines Reveal Complex Baseline Variationsbetween Individuals. This paper describes results from a 14-week study of healthy human subjects using ultrasensitive single-molecule array (Simoa) assays to measure both intra and intersubject variation of 15 cytokines. READ

2018 January Mesenchymal stromal cell infusionmodulates systemic immunological responsesin stableCOPD patients:A phase I pilot study Mesenchymal stromal cell infusion may provide an alternative immune-based therapeutic option for COPD patients READ

2018 January A phase I study for intravenous autologous mesenchymal stromal cell administrationto patients with severe emphysema Background: Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema. READ

2018 January Mesenchymal stromal cell infusion may provide an alternative immune-based therapeutic option forCOPD patients We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route. READ

2018 April Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines. Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging. READ

2018 April Mesenchymal stromal cells: a noveltherapy for the treatment of chronicobstructive pulmonary disease? COPD is characterised by tissue destruction and inflammation. READ

2018 April Autologous Stromal Vascular Fraction inthe Intravenous Treatment of End-StageChronic Obstructive Pulmonary Disease:A Phase I Trial of Safety and Tolerability Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treat- ment exists capable of either reversing or even interrupting its course. READ

2018 May Gut, Microbiome, and Brain Regulatory Axis:Relevance to Neurodegenerative and PsychiatricDisorders. It has become apparent that the molecular and biochemical integrity of interactive families, genera, and species of human gut microflora is critically linked to maintaining complex metabolic and behavioral processes mediated by peripheral organ systems and central nervous system neuronal groupings. READ

2018 June Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases. In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in the gut. Parkinson’s disease (PD) is the most intensively studied neurodegenerative disease in this context. READ

2018 July Microbiome in the Gut-Skin Axis in Atopic Dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin condition with a drastic impact on pediatric health. READ

2018 November Clinical Application of Mesenchymal StemCell-Derived Extracellular Vesicle-BasedTherapeutics for Inflammatory LungDiseases It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication. READ

2018 November A comparison of biofluid cytokine markers across platform technologies: T Correspondence or divergence? Quantification of biofluid cytokines is a rapidly growing area of translational research. READ

2018 November Therapeutic Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewalcharacteristics and the abilityto differentiate intotissue-specific cells. Multipotent mesenchymal stem/stromal cells (MSCs) possess robust self-renewal characteristics and the ability to differentiate into tissue-specific cells. READ

2018 November Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis. Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints. READ

Scientific content reviewed by the Bioscience Institute Scientific Board. · Last updated 2025-09-24

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Periodic monitoring of the four biological drivers that precede cancer, through five laboratory protocols.

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