Exercise as a Mean to Control Low-Grade Systemic Inflammation.
Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide.
Causes and consequences of low grade endotoxemia and inflammatory diseases.
Increasing clinical observations reveal that persistent low-grade inflammation is associated with the pathogenesis of severe chronic diseases such as atherosclerosis, diabetes, and aging-related neurological diseases.
Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response.
Peripheral inflammation is associated with remote global gene expression changes in the brain.
Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur.
Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia.
Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others.
Additive Contributions of Childhood Adversity and Recent Stressors to Inflammation at Midlife: Findings from the MIDUS Study.
We sought to examine the joint contributions of self-reported adverse childhood experiences (ACEs) and recent life events (RLEs) to inflammation at midlife, by testing three competing theoretical models: stress generation, stress accumulation, and early-life stress sensitization.
Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes.
Exercise physiology research has identified individual biomarkers for assessing health, performance, and recovery during exercise training. However, there are few recommendations for biomarker panels for tracking changes in individuals participating in physical activity and exercise training programs.
Allogeneic Mesenchymal Stem Cells AmeliorateAging Frailty: A Phase II Randomized,Double-Blind, Placebo-Controlled Clinical Trial.
Frailty confers an increased vulnerability to adverse health outcomes and mortality in response to stressors. The frailty syndrome is driven mostly by biological aging processes that include inflammation and stem cell dysfunction, as opposed to chronological aging
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and therole of nutrition.
Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions.
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines.
Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging.
Gut, Microbiome, and Brain Regulatory Axis:Relevance to Neurodegenerative and PsychiatricDisorders.
It has become apparent that the molecular and biochemical integrity of interactive families, genera, and species of human gut microflora is critically linked to maintaining complex metabolic and behavioral processes mediated by peripheral organ systems and central nervous system neuronal groupings.
Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases.
In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in the gut. Parkinson’s disease (PD) is the most intensively studied neurodegenerative disease in this context.