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Biomolecular Pathology: Clinical Studies

Published studies on biomolecular pathology

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1994 October Circulating proinflammatory cytokines (IL-1 beta, TNF-alpha, and IL-6) and IL-1 receptor antagonist (IL-1Ra) in fulminant hepatic failure and acute hepatitis. Fulminant hepatic failure (FHF) is characterized by massive necroinflammation of the liver tissue and is associated with high mortality. READ

2003 February The Serum Levels of IL-1β, IL-6, IL-8 and TNF-α in Nonalcoholic Fatty Liver. Nonalcoholic fatty liver (NAFL) has an extensive clinical spectrum ranging from simple fatty liver to steatohepatitis and cirrhosis. Its pathogenesis is multifactorial. READ

2003 April Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. The purpose of the current study was to test the hypothesis that an altered fat distribution in elderly healthy subjects and in patients with type-2 diabetes contributes to high circulating levels of interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha, which secondly is related to lower muscle mass. READ

2003 October IL-6, TNF-α and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort. There are no satisfactory data on circulating concentrations of inflammatory cytokines and their potential relationship with traditional and nontraditional atherosclerosis risk factors in a large healthy young population. READ

2005 October Serum Levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity. Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. READ

2013 March Cytokine Levels in the Serum of Healthy Subjects. Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. READ

2013 December Baseline Levels and Temporal Stability of 27 Multiplexed Serum Cytokine Concentrations in Healthy Subjects. Cytokines are humoral molecules that elicit regulatory function in immunologic pathways. READ

2019 January White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism. Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by social communication deficits and the presence of restricted interests and repetitive behaviors. READ

Scientific content reviewed by the Bioscience Institute Scientific Board. · Last updated 2019-07-03

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