2006 May
Aging, inflammation and cancer.
Aging is a key aspect of neoplasia at the level of cells, individuals and populations.
2009 December
Articular Cartilage Regeneration With Autologous Marrow Aspirate and Hyaluronic Acid.
The purpose of the study was to determine whether postoperative intra-articular injections of autologous marrow aspirate (MA) and hyaluronic acid (HA) after subchondral drilling resulted in better cartilage repair as assessed histologically by Gill scoring.
Ortho
2006 May
Stem cells for the repair and regeneration of bone
There continues to be a need for novel therapies directed at bone repair and regeneration in modern orthopaedics.
2007 July
Healing Full-Thickness Cartilage Defects Using Adipose-Derived Stem Cells.
The purpose of this study was to evaluate the use of adipose-derived stem cells (ADSCs) as a source for full-thickness cartilage repair in an animal model.
2009 January
Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
Mesenchymal stem cells (MSCs) represent a promising tool for new clinical concepts in supporting cellular therapy.
2012 March
June 2012, Volume 36, Issue 2, pp 139–148 | Cite as Isolation, culture and chondrogenic differentiation of canine adipose tissue- and bone marrow-derived mesenchymal stem cells–a comparative study.
In the dog, mesenchymal stem cells (MSCs) have been shown to reside in the bone marrow (bone marrow-derived mesenchymal stem cells: BM-MSCs) as well as in the adipose tissue (adipose tissue-derived stem cells: ADSCs).
2012 November
A Novel, Minimally-Invasive Technique of Cartilage Repair in the Human Knee Using Arthroscopic Microfracture and Injections of Mesenchymal Stem Cells and Hyaluronic Acid—A Prospective Comparative Study on Safety and Short-Term Efficacy.
Most current cell-based cartilage repair techniques require some form of scaffolds and 2 separate surgical procedures.
2013 April
Articular Cartilage Regeneration With Autologous Peripheral Blood Stem Cells Versus Hyaluronic Acid: A Randomized Controlled Trial.
The purpose of this study was to compare histologic and magnetic resonance imaging (MRI) evaluation of articular cartilage regeneration in patients with chondral lesions treated by arthroscopic subchondral drilling followed by postoperative intra-articular injections of hyaluronic acid (HA) with and without peripheral blood stem cells (PBSC).
2014 January
Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.
There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee.
2014 January
Effect of Intraarticular Injection of Autologous Adipose-Derived Mesenchymal Stem and Regenerative Cells on Clinical Signs of Chronic Osteoarthritis of the Elbow Joint in Dogs.
The field of adipose-derived mesenchymalstem cell (AD-MSC) therapy in regenerative medicine is a rapidly growing area of research,and stem cell therapy is being used to treat os-teoarthritis (OA).
2014 January
Adipose-Derived Mesenchymal Stem Cells for the Treatment of Articular Cartilage: A Systematic Review on Preclinical and Clinical Evidence.
Among the current therapeutic approaches for the regeneration of damaged articular cartilage, none has yet proven to offer results comparable to those of native hyaline cartilage.
2014 January
Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial.
Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation.
2014 August
Does an Injection of a Stromal Vascular Fraction Containing Adipose-Derived Mesenchymal Stem Cells Influence the Outcomes of Marrow Stimulation in Osteochondral Lesions of the Talus?: A Clinical and Magnetic Resonance Imaging Study.
Marrow stimulation for the treatment of osteochondral lesions of the talus (OLTs) is controversial in patients with poor prognostic factors of OLTs.
2015 January
Adipose-Derived Stromal Cells Protect Intervertebral Disc Cells in Compression: Implications for Stem Cell Regenerative Disc Therapy.
Abnormal biomechanics plays a role in intervertebral disc degeneration. Adipose-derived stromal cells (ADSCs) have been implicated in disc integrity; however, their role in the setting of mechanical stimuli upon the disc's nucleus pulposus (NP) remains unknown.
2015 April
Regenerative Treatments to Enhance Orthopedic Surgical Outcome.
In orthopedic surgery there has been a never-ending quest to improve surgical outcome and the patient's experience.
2016 April
Biologic Treatments for Sports Injuries II Think Tank—Current Concepts, Future Research, and Barriers to Advancement, Part 3.
Focal chondral defects of the articular surface are a common occurrence in the field of orthopaedics.
2016 May
Mesenchymal Stem Cells and Their Clinical Applications in Osteoarthritis.
Osteoarthritis is a chronic degenerative joint disorder characterized by articular cartilage destruction and osteophyte formation.
2016 June
Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments.
Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative joint diseases such as osteoarthrtis.
2016 June
Guidance for Industry Preparation of IDEs and INDs for Products Intended to Repair or Replace Knee Cartilage.
This guidance document provides to you, sponsors of an investigational device exemption application (IDE) or an investigational new drug application (IND), recommendations about certain information that should be included in a submission describing a product intended to repair or replace knee cartilage.
2016 June
Clinical Outcomes of Mesenchymal Stem Cell Injection With Arthroscopic Treatment in Older Patients With Osteochondral Lesions of the Talus.
The ideal treatment for osteochondral lesions of the talus (OLTs) is still controversial, especially in older patients.Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions.
2016 June
Osteoarthritis in Other Joints (Hip, Elbow, Foot, Ankle, Toes, Wrist) after Sports Injuries.
Osteoarthritis of nonknee joints, although less common than knee osteoarthritis, remains a significant and disabling condition for many present and former athletes.
2016 July
Human Multipotent Mesenchymal Stromal Cells in the Treatment of Postoperative Temporal Bone Defect: An Animal Model.
Canal wall down mastoidectomy is one of the most effective treatments for cholesteatoma.
2016 August
A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.
Autologous mesenchymal stem cells (MSCs) have been utilized to treat degenerative and post-traumatic orthopedic conditions for more than two decades.
2016 August
A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.
Autologous mesenchymal stem cells (MSCs) have been utilized to treat degenerative and post-traumatic orthopedic conditions for more than two decades.
2017 March
Mesenchymal stem cell therapy in the treatment of hip osteoarthritis.
This study was performed to investigate the safety and efficacy of the intra-articular infusion of ex vivo expanded autologous bone marrow-derived mesenchymal stem cells (BM-MSC) to a cohort of patients with articular cartilage defects in the hip.
2017 April
Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis.
The aim of this study was to evaluate the therapeutic efficacy and safety of mesenchymal stem cells (MSCs) for the treatment of patients with knee osteoarthritis (OA).
2017 August
Adipose derived stem cells for Orthopedic application: A new Frontier.
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine.
2017 August
Adipose-derived stromal cell in regenerative medicine: A review
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine.
2017 August
Adipose-derived stromal cell in regenerative medicine: A review
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine.
2017 October
Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation?
Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis.
2018 January
A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
Osteoarthritis (OA) is a degenerative disease characterized by loss of cartilage and increased subchondral bone within synovial joints.
2018 July
Mesenchymal Stem Cells in Combination with Hyaluronic Acid for Articular Cartilage Defects.
Mesenchymal stem cells (MSCs) and hyaluronic acid (HA) have been found in previous studies to have great potential for medical use.
2018 August
Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study.
Colorectal cancer (CRC) is a common malignant gastrointestinal tumor.
2018 September
Identification of the Human Skeletal Stem Cell.
Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored.
2018 September
Osteogenesis and aging: lessons from mesenchymal stem cells.
Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures.
2018 November
Limited evidence for adipose-derived stem cell therapy on the treatment of osteoarthritis.
The purpose of this systematic review is to evaluate the effects of adipose derived mesenchymal stem cells (ADSCs) in the treatment of osteoarthritis (OA) in the clinical setting.
2018 November
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.
Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints.
2018 December
Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue.
Treatment of focal lesions of the articular cartilage of the knee using chondrocytes in a hyaluronic acid (HA) scaffold is already being investigated in clinical trials.
2018 December
Umbilical Cord‐Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose‐derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement in focal or diffuse disease.
Pulmonary Disease
2016 January
A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema
Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema.
2016 January
Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease
The increasingly high rates of morbidity and mortality due to acute and chronic lung diseases have emerged as one of the major public health issues globally.
2016 January
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions.
2017 May
Mesenchymal stem cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a major cause of respiratory failure in critically ill patients and common outcome of various lung interstitial diseases.
2017 July
Mesenchymal Stem Cells in Fibrotic Disease
Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation.
2017 August
Adipose-derived stromal cell in regenerative medicine: A review.
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine.
2017 August
Autologous Stromal Vascular Fraction in the Intravenous Treatment of End-Stage Chronic Obstructive Pulmonary Disease: A Phase I Trial of Safety and Tolerability
Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treat- ment exists capable of either reversing or even interrupting its course.
2018 April
Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route.
2018 April
Mesenchymal stromal cell infusion modulates systemic immunological responses in stable COPD patients: A phase I pilot study
COPD is characterised by tissue destruction and inflammation. Given the lack of curative treatments and the progressive nature of the disease, new treatments for COPD are highly relevant.
2018 April
Combined Bone Marrow‐Derived Mesenchymal Stromal Cell Therapy and One‐Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial
One‐way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients.
2018 April
Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats
Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured.
2018 July
Mesenchymal Stem Cell Therapy of Pulmonary Fibrosis: Improvement with Target Combination
Although the clinical application of new drugs has been shown to be effective in slowing disease progression and improving the quality of life in patients with pulmonary fibrosis, the damaged lung tissue does not recover with these drugs.
2018 July
Clinical applications of mesenchymal stem cells in chronic lung diseases
Mesenchymal stem (stromal) cells (MSCs) are multipotent stromal cells that have the ability to modulate immune response to tissue injury and promote repair in vivo.
2018 August
Cell Therapy in Idiopathic Pulmonary Fibrosis
diopathic pulmonary fibrosis is a fatal disease with no effective or curative treatment options.
2018 September
Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury
Alveolar epithelial dysfunction induced by hypoxic stress plays a significant role in the pathological process of lung ischemia-reperfusion injury (IRI).
2018 October
Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication.
2018 October
Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report
Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis.
2018 November
Off-label mesenchymal stromal cell treatment in two infants with severe bronchopulmonary dysplasia: clinical course and biomarkers profile
Bronchopulmonary dysplasia (BPD) is the most prevalent sequelae of premature birth, for which therapeutic options are currently limited.
2018 November
Mesenchymal Stem Cells for the Treatment of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is an inexorably progressive lung disease of unknown origin
2018 November
Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?
COPD is characterised by tissue destruction and inflammation.
2018 December
Stem Cell Delivery with Polymer Hydrogel for Treatment of Intervertebral Disc Degeneration: From 3D Culture to Design of the Delivery Device for Minimally Invasive Therapy.
Nucleus pulposus (NP) tissue damage can induce detrimental mechanical strain on the biomechanical performance of intervertebral discs (IVDs), causing subsequent disc degeneration.
Anti-Aging
2017 August
Adipose-derived stromal cell in most of the regenerative medicine.
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine.
2018 January
Gut Dysbiosis and Muscle Aging.
Advanced age is characterized by several changes, one of which is the impairment of the homeostasis of intestinal microbiota.
2018 November
Gut microbiota and aging.
Given this perspective, looking at the mutual influence between microbiota products, inflammation mediators and immune system, the modulation of gut microbiota may help to facilitate a physiological and non-pathological aging process and, perhaps, to contrast the progression of degenerating mechanisms.
