A phase I study for intravenous autologous mesenchymal stromal cell administration
to patients with severe emphysema
Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema.
Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary
The increasingly high rates of morbidity and mortality due to acute and chronic lung diseases have emerged as one of the major public health issues globally.
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the
role of nutrition
Ageing is characterised by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defence, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions.
Mesenchymal stem cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a major cause of respiratory failure in critically ill patients and common outcome of various lung interstitial diseases.
Mesenchymal Stem Cells in
Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation.
Adipose-derived stromal cell in
regenerative medicine: A review.
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine.
Autologous Stromal Vascular Fraction in
the Intravenous Treatment of End-Stage
Chronic Obstructive Pulmonary Disease:
A Phase I Trial of Safety and Tolerability
Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treat- ment exists capable of either reversing or even interrupting its course.
Effects of different mesenchymal stromal
cell sources and delivery routes in
We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route.
Mesenchymal stromal cell infusion
modulates systemic immunological
responses in stable COPD patients:
A phase I pilot study
COPD is characterised by tissue destruction and inflammation. Given the lack of curative treatments and the progressive nature of the disease, new treatments for COPD are highly relevant.
Combined Bone Marrow‐Derived Mesenchymal Stromal Cell Therapy and One‐Way Endobronchial Valve Placement
in Patients with Pulmonary Emphysema:
A Phase I Clinical Trial
One‐way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients.
Transplantation of adipose-derived mesenchymal
stem cells attenuates pulmonary fibrosis of silicosis
via anti-inflammatory and anti-apoptosis effects in
Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured.
Mesenchymal Stem Cell Therapy of Pulmonary
Fibrosis: Improvement with Target Combination
Although the clinical application of new drugs has been shown to be effective in slowing disease progression and improving the quality of life in patients with pulmonary fibrosis, the damaged lung tissue does not recover with these drugs.
Clinical applications of mesenchymal
stem cells in chronic lung diseases.
Mesenchymal stem (stromal) cells (MSCs) are multipotent stromal cells that have the ability to modulate immune response to tissue injury and promote repair in vivo.
Cell Therapy in Idiopathic Pulmonary
diopathic pulmonary fibrosis is a fatal disease with no effective or curative treatment options.
Human Mesenchymal Stem Cell
Secretome from Bone Marrow or Adipose-Derived
Tissue Sources for Treatment of
Hypoxia-Induced Pulmonary Epithelial
Alveolar epithelial dysfunction induced by hypoxic stress plays a significant role in the pathological process of lung ischemia-reperfusion injury (IRI).
Clinical Application of Mesenchymal Stem
Cell-Derived Extracellular Vesicle-Based
Therapeutics for Inflammatory Lung Diseases
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication.
Clinical observation of umbilical cord mesenchymal stem cell treatment of
severe idiopathic pulmonary fibrosis:
A case report
Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis.
Off-label mesenchymal stromal cell treatment in two infants with severe bronchopulmonary dysplasia: clinical
course and biomarkers profile
Bronchopulmonary dysplasia (BPD) is the most prevalent sequelae of premature birth, for which therapeutic options are currently limited.
Mesenchymal Stem Cells for the
Treatment of Idiopathic Pulmonary
Idiopathic pulmonary fibrosis (IPF) is an inexorably progressive lung disease of unknown origin
Mesenchymal stromal cells: a novel
therapy for the treatment of chronic
obstructive pulmonary disease?
COPD is characterised by tissue destruction and inflammation.
Stem Cell Delivery with Polymer Hydrogel
forTreatment of Intervertebral Disc Degeneration:
From 3D Culture to Design of the Delivery Device for Minimally
Nucleus pulposus (NP) tissue damage can induce detrimental mechanical strain on the biomechanical performance of intervertebral discs (IVDs), causing subsequent disc degeneration.